SCIENTISTS made a major step towards understanding why older women are more likely to produce abnormal eggs, increasing the risk of conditions such as Down's syndrome, it (Source: Scotsman.com News - Health of the NHS)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Scientists have a taken major step towards understanding why older women are more likely to produce abnormal eggs, increasing the risk of infertility, miscarriage and birth defects such as Down's syndrome. (Source: Telegraph Health)

UK research identifying loss of key protein in mice eggs is seen as a breakthrough that may help prevent birth defectsScientists have made a breakthrough in understanding why older women become less fertile, suffer a miscarriage or have a baby with Down's syndrome.The discovery could ultimately lead to treatments that would increase the chances of a successful pregnancy for growing numbers of would-be mothers in their late 30s and early 40s.Researchers led by Dr Mary Herbert, an expert in reproductive biology at Newcastle University's Institute for Ageing and Health, have identified why some older women produce abnormal eggs, according to findings published in the journal Current Biology.It has been known for a long time that would-be mothers who are nearing the end of their fertility are ...

Conclusions Seventeen per cent of patients with Down's syndrome living in residential centres had undiagnosed CHD, and valvular regurgitation was present in the majority of patients. Cardiac screening is recommended in older Down's syndrome patients, for whom new therapeutic options are available and for prevention of cardiac complications in old age. (Source: Heart)

Authors: Blanco-González A, Alvarez-Vázquez A, Mesa-Alvarez A, Calvo-Blanco J PMID: 20800046 [PubMed - in process] (Source: Actas Urologicas Espanolas)

A new battery of tests taking only two hours can assess the best drug and behavioral help for children with Down syndrome. The tests, developed at the UA, use non-language dependent computer exercises to determine the developmental trajectory of those with the condition. (Source: Health)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

TUCSON, Aug. 30 (UPI) -- A new battery of tests taking only 2 hours can assess the best drug and behavioral help for children with Down syndrome, U.S. researchers say. Down syndrome - Genetic disorder - United States - Health - Conditions and Diseases (Source: Health News - UPI.com)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

TUCSON, Aug. 30 (UPI) -- A new battery of tests taking only 2 hours can assess the best drug and behavioral help for children with Down syndrome, U.S. researchers say. Down syndrome - Genetic disorder - United States - Health - Conditions and Diseases (Source: Health News - UPI.com)

Acta Ophthalmol. 2010: 88: e196–e204 (Source: Acta Ophthalmologica)

Acta Ophthalmol. 2010: 88: e196–e204 (Source: Acta Ophthalmologica)

Neuroscientists in the Down Syndrome Research Group at the University of Arizona have created a battery of tests that quickly aid in the assessment of the cognitive abilities of persons with Down syndrome. The UA collaborated on the development of the tests with colleagues at Johns Hopkins University and Emory University. The tests - a series of computer exercises that are not language dependent - offer clinicians and other researchers a new tool that can help determine both the developmental trajectory of those with Down syndrome and aid in devising drug and behavioral interventions... (Source: Health News from Medical News Today)

The National Down Syndrome Congress of the U.S. is taking Emmy organizers to task for nominating the song Down Syndrome Girl for an award for outstanding original music and lyrics. (Source: CBC | Health)

(Source: Prenatal Diagnosis)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

The authors studied a group of older carers of aging adults with Down syndrome (DS) to ascertain what effects such caregiving may have on them given the presence or possibility of age-associated decline or dementia. The study also examined the comparative levels of care provided, key signs noted when decline was beginning, the subjective burden experienced, and what were the key associated health factors when carers faced a changed level of care. The authors found that this group was made up of long-term, committed carers who have decided early on to look after their relative with DS over their lifetime. When faced with the onset and ongoing progression of dementia, their commitment was still evident as evidenced by adopting physical accommodations and finding ways to continue to provide c...

Author Summary In meiosis, sex cells that become eggs or sperm undergo a single round of DNA replication followed by two consecutive chromosomal divisions. In most organisms, the segregation of chromosomes at the first meiotic division is dependent upon at least one genetic exchange, or crossover event, between homologous chromosome pairs. Matched chromosomes that do not receive a crossover frequently undergo non-disjunction at the first meiotic division, yielding gametes that lack chromosomes or contain additional copies. Such missegregation events have been linked to Down syndrome and human infertility. This paper focuses on Msh4-Msh5, a complex required for the proper segregation of homologous chromosomes during the Meiosis I division. We performed a mutational analysis of the baker's ...

In a study of egg cells using time-lapse microscopy, researchers at the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered an unusual property of meiosis - cell division that produces reproductive cells in sexually reproducing organisms. The discovery of an "inside out" mechanism by which egg cell chromosomes separate from each other may shed light on mistakes made in chromosome distribution that can lead to Down syndrome, high miscarriage rates in humans, and the age-related decrease in fertility in human females... (Source: Health News from Medical News Today)

The Arizona Cognitive Test Battery, designed by UA psychologists Lynn Nadel and Jamie Edgin, can quickly and easily assess the cognitive abilities of persons with Down syndrome. It gives clinicians and other researchers a tool to help determine the life trajectory of those with the genetic disorder as well as aid in the development of treatments. (Source: Health)

(University of Arizona) The Arizona Cognitive Test Battery, designed by UA psychologists Lynn Nadel and Jamie Edgin with collaborators at Johns Hopkins and Emory, can quickly assess the cognitive abilities of persons with Down syndrome. It gives clinicians and other researchers a tool to help determine the life trajectory of those with the genetic disorder as well as aid in the development of treatments. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Researchers Experimenting with Treatments for Down Syndrome, Childhood Leukemia Examine Judge's Ruling (Source: Health News: CBSNews.com)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Researchers Experimenting with Treatments for Down Syndrome, Childhood Leukemia Examine Judge's Ruling (Source: Health News: CBSNews.com)