Conclusions: Semantic errors are common among all types of primary progressive aphasia and poststroke aphasia, and the type of error depends in part on the location of damage. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (Source: Neuropsychology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusion: This method is useful for preoperative localization of the speech area, as well as preoperative planning of the operative approach and intra-operative planning of the direction of brain retraction and operative corridor. (Source: Clinical Neurology and Neurosurgery)

Conclusions Behavioural speech–language therapy improves non-fluent aphasia, independent of cortical stimulation. However, epidural stimulation of the ipsilesional premotor cortex may augment this effect, with the largest effects after completion of therapy. The neural mechanisms underlying these effects are manifested in the brain by decreases in the volume of activity globally and in particular regions. Although the number of participants enrolled in this trial precludes definitive conclusions, targeted epidural cortical stimulation appears safe and may be a feasible adjunctive treatment for non-fluent aphasia, particularly when the aphasia is more severe. (Source: Journal of Neurology, Neurosurgery and Psychiatry)

Researchers are looking at whether motion sensing technologies, such as those used by the Nintendo Wii, could be used in the rehabilitation of people with aphasia. (Source: EHI Primary Care)

The V363I mutation of the microtubule-associated protein tau gene has previously been associated with a case of primary progressive nonfluent aphasia with variable penetrance. Herein, we report the finding of the V363I variation in a sporadic early onset frontotemporal dementia patient and in several members of her family. The V363I variation was associated with frontotemporal dementia only in the proband which was also homozygous for the A allele of the progranulin single-nucleotide polymorphism rs9897526 and for methionine at codon 129 of the prion protein gene. The microtubule-associated protein tau V363I variation could be considered either an incomplete penetrant mutation or a rare polymorphism; although its pathogenicity has yet to be clearly demonstrated, modifier genetic factors se...

CONCLUSIONS: Script training was successful and functional for clients with AoS. Clients reported increased confidence, speaking ease, and speech naturalness. Although scripts did not become errorless, clients retained their scripts and reported using them frequently. Whether principles of motor learning may have promoted the long term retention of scripts exhibited by participants must be determined through future research. PMID: 20739633 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Motion sensing technologies, such as the Nintendo Wii Remote, could be used in the rehabilitation of people with aphasia - a language impairment, commonly caused by a stroke, that affects around 250,000 people in the UK1. The research is being carried out by a team at City University London, in collaboration with the Stroke Association and funded by the Engineering and Physical Sciences Research Council (EPSRC)... (Source: Health News from Medical News Today)

Test your knowledge with this imaging case challenge of a 44-year-old man with transient dysphasia and extremity numbness. Medscape Neurology & Neurosurgery (Source: Medscape Today Headlines)

(Engineering and Physical Sciences Research Council) Motion sensing technologies, such as the Nintendo Wii Remote, could be used in the rehabilitation of people with aphasia -- a language impairment, commonly caused by a stroke, that affects around 250,000 people in the UK. (Source: EurekAlert! - Medicine and Health)

CONCLUSION: The present study has further established the external validity of MC analysis in Cantonese. Future investigations involving more speakers with aphasia will allow adequate description of its psychometric properties. PMID: 20719865 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

Conclusions & Implications: Further research is required to extend findings by investigating how speech-language pathologists address identified themes in clinical practice. To improve service provision, continued reflection by speech-language pathologists on how services provided align with client's values and priorities is a necessity. A commitment by speech-language pathologists to work in partnership with people with aphasia and their families and friends to achieve successful living with aphasia is one way to translate this research into practice. PMID: 20716031 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

Abstract  Frontotemporal dementias are syndromes of progressive dysfunction of the frontal and/or temporal lobes, either unilaterally or bilaterally. These syndromes were described clinically under the terms “primary progressive aphasia” in the United States and “frontotemporal dementia” in Europe and the United Kingdom. They are diagnosed by the clinical features of a frontal lobe neurobehavioral syndrome, or a language and cognitive deterioration. In recent years, molecular genetic findings in these syndromes, especially the tau and progranulin mutations on chromosome 17, have provided a molecular and genetic foundation for the understanding of frontotemporal dementia. These disorders are distinct from Alzheimer’s disease but have some overlap with the syndrome ...

Authors: Theodore WH There is relatively little information on the underlying parameters that affect clinical features of the postictal period. Age-related physiological changes, including alterations in cerebral blood flow and metabolism, neurotransmitter function, and responses of the brain to seizure activity may affect postictal clinical phenomena. Some conclusions can be drawn. Elderly adults and children, particularly in the presence of diffuse cerebral dysfunction, may have more prolonged postictal confusion. Postictal dysphasia strongly suggests a dominant hemisphere focus, more often temporal, and Todd's paralysis is always contralateral to the epileptogenic zone. Much additional information could be derived from the vast amount of video/EEG monitoring data available. PMID...

Conclusion: Nonfluent speech in PNFA may be due in part to difficulty with grammatic processing associated with left inferior frontal and anterior-superior temporal disease. (Source: Neurology)

Conclusions: Neither PPA phenotyping nor imaging alone is a reliable predictor of pathology. Multimodal predictors, such as combining neuropsychological testing with MRI analysis, can improve noninvasive prediction of underlying pathology in nonfluent forms of PPA. (Source: Neurology)

Conclusion: PPA with AOS is aligned with the syndrome previously designated progressive nonfluent aphasia; agrammatism may emerge as the syndrome evolves, or alternatively, the pure AOS group may be pathophysiologically distinct. PPA without AOS resembles the syndrome designated logopenic/phonologic aphasia; however, there is evidence for a distinct subsyndrome of GRN-associated aphasia. The findings provide a rationale for further longitudinal studies with pathologic correlation. (Source: Neurology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.

(Source: Neurology)

Conclusions: Over the first year after stroke, participants reported that the process of community reintegration was marked by ongoing changes in their goals. Formal and informal caregivers need to work with stroke survivors living in the community to facilitate realistic and achievable goal setting. Tools which identify meaningful activities should also be incorporated to provide stroke survivors with the opportunity to contribute and engage with others in the community. PMID: 20713436 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)

Conclusion. PWA participated in fewer activities and reported worse quality of life after stroke than people without aphasia, even when their physical abilities, well-being and social support were comparable. Implications for clinical practice and future research are discussed. PMID: 20712416 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)

Abstract  In this paper, a historical overview of the interpretation of conduction aphasia is initially presented. It is emphasized that the name conduction aphasia was proposed by Wernicke and was interpreted as a disconnection between the temporal and frontal brain language areas; this interpretation was re-taken by Geschwind, attributing the arcuate fasciculus the main role in speech repetition disturbances and resulting in the so-called Wernicke-Geschwind model of language. With the introduction of contemporary neuroimaging techniques, this interpretation of conduction aphasia as a disconnection syndrome due to an impairment of the arcuate fasciculus has been challenged. It has been disclosed that the arcuate fasciculus does not really connect Wernicke’s and Broca’s...